Modulation of Multispecific Transporters by Uncaria tomentosa Extract and Its Major Phytoconstituents.

ABSTRACT: Background/Objectives: One of the major risks associated with the concomitant use of herbal products and therapeutic drugs is herb-drug interactions (HDIs). The most common mechanism leading to HDIs is the inhibition and/or induction of transport proteins and drug-metabolizing enzymes by herbal ingredients, causing changes in the pharmacokinetic disposition of the victim drug. The present study aimed to determine the potential interactions of Uncaria tomentosa (UT) (cat's claw), a popular herb due to its supposed health benefits. Methods: The effect of UT extract and its major oxindole alkaloids was investigated on multispecific solute carrier (SLC) and ATP-binding cassette (ABC) drug transporters, using SLC transporter-overexpressing cell lines and vesicles prepared f

SUBMITTER: Szilvasy N 

PROVIDER: S-EPMC11597817 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature