In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II.

ABSTRACT:

Background

Sulfonamide acridine derivatives have garnered significant attention from medicinal chemists due to their diverse range of biological activities.

Methods

In this study, eleven compounds were synthesized according to the literature, and their impact on cell growth inhibition, induction of apoptosis, and cell cycle distribution were assessed in three different cell lines. Their inhibitory effects on the topoisomerase (Topo) I and II were investigated in vitro. Molecular docking studies were conducted to predict the binding affinities of these compounds for crystallized downloaded topoisomerases.

Results

The compounds were examined in vitro for their anticancer activity against human hepatic (HepG2) colon (HCT-8) and breast (MCF-7) carcinoma cell lines. Compou

SUBMITTER: Badr M 

PROVIDER: S-EPMC11597879 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature