Peptide Toxin Diversity and a Novel Antimicrobial Peptide from the Spider <i>Oxyopes forcipiformis</i>.

ABSTRACT: Spider venoms are emerging as a rich source of bioactive peptide toxins with therapeutic potential. Lynx spiders of the genus Oxyopes are small, cursorial hunters that employ complex venom to subdue arthropod prey. However, extracting crude venom from these diminutive arachnids poses significant challenges. This study presents a transcriptome analysis of venom glands from an undescribed Oxyopes forcipiformis species, revealing 339 putative protein and peptide toxin sequences categorized into seven functional groups. The venom composition was dominated by membrane-active peptides (40.71%), venom auxiliary proteins (22.71%), neurotoxins (15.63%), channel active peptides (7.08%) and uncharacterized components (13.87%). Additionally, phylogenetic analysis of 65 disulfide-bond-ric

SUBMITTER: Wang K 

PROVIDER: S-EPMC11597926 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature