Screening and Immune Efficacy Evaluation of Antigens with Protection Against Feline Calicivirus.

ABSTRACT:

Background

Feline calicivirus (FCV), a pathogen that causes upper respiratory tract diseases in felids, primarily leads to oral ulcers and various respiratory symptoms, which can be fatal in severe cases. Currently, FCV prevention and control rely primarily on vaccination; however, the existing vaccine types in China are mainly inactivated vaccines, leading to a single prevention and control method with suboptimal outcomes.

Methods and results

This study commences with a genetic evolution analysis of Chinese FCV isolates, confirming the presence of two major genotypes, GI and GII with GI emerging as the dominant form. We subsequently selected the broadly neutralizing vaccine candidate strain DL39 as the template for the truncation and expression of multiple recombinant prote

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11598032 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature