Machine Learning Framework for Conotoxin Class and Molecular Target Prediction.

ABSTRACT: Conotoxins are small and highly potent neurotoxic peptides derived from the venom of marine cone snails which have captured the interest of the scientific community due to their pharmacological potential. These toxins display significant sequence and structure diversity, which results in a wide range of specificities for several different ion channels and receptors. Despite the recognized importance of these compounds, our ability to determine their binding targets and toxicities remains a significant challenge. Predicting the target receptors of conotoxins, based solely on their amino acid sequence, remains a challenge due to the intricate relationships between structure, function, target specificity, and the significant conformational heterogeneity observed in conotoxins with the same pr

SUBMITTER: Truong DP 

PROVIDER: S-EPMC11598409 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature