Shortened sleep duration impairs adipose tissue adrenergic stimulation of lipolysis in postmenopausal women.

ABSTRACT:

Objective

The objective of this study was to examine the changes in adipose tissue lipolytic capacity and insulin signaling in response to shortened sleep duration (SSD) in postmenopausal women.

Methods

Adipose tissue from a randomized crossover study of nine healthy postmenopausal women (mean [SD], age: 59 [4] years; BMI: 28.0 [2.6] kg/m²) exposed to four nights of habitual and SSD (60% of habitual sleep) while following a eucaloric diet was examined ex vivo. Tissue lipolytic capacity was determined by measurement of secreted glycerol. Cellular insulin signaling was determined by measuring insulin-mediated changes in Akt phosphorylation. RNA sequencing examined global transcriptional changes.

Results

With SSD, basal glycerol secretion was reduced, and isop

SUBMITTER: Singh P 

PROVIDER: S-EPMC11598667 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature