Intranasal M2SR and BM2SR Vaccine Viruses Do Not Shed or Transmit in Ferrets.

ABSTRACT:

Background/objectives

Live influenza vaccines are considered to stimulate better overall immune responses but are associated with safety concerns regarding shedding and the potential for transmission or reassortment with wild-type influenza viruses. Intranasal M2SR and BM2SR (M2- and BM2-deficient single replication), intranasal influenza viruses, have shown promise as broadly cross-reactive next-generation influenza vaccines. The replication deficiency, shedding, and transmissibility of M2SR/BM2SR viruses were evaluated in a ferret model.

Methods

Wild-type influenza A and B control viruses replicated in upper respiratory organs and transmitted to both direct and aerosol contact ferrets, whereas M2SR and BM2SR influenza vaccine viruses were not detected in any tissues or in

SUBMITTER: Hatta Y 

PROVIDER: S-EPMC11598709 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature