Hepatitis A Seroprevalence Among HIV-Exposed and Unexposed Pediatric Populations in South Africa.

ABSTRACT: Background: There is limited evidence comparing hepatitis A seroprevalence among HIV-exposed uninfected (HEU), HIV-infected (HIV), and unexposed uninfected (HUU) children. This compromises rational vaccine decision-making. Methods: This study comprised a retrospective health facility-based population of children aged 1 month-12 years. Archival sera were tested for markers of acute (anti-HAV IgM) or past (total anti-HAV) HAV infection. Subgroup analysis was conducted based on perinatal HIV exposure or infection status. Results: Among 513 children, the median age was 10 (IQR: 4-25) months. The median maternal age was 29 (IQR: 25-34) years. An anti-HAV seropositivity of 95.1% (117/122 [95% CI 90.2-98.4]) was found among those ≤6 months of age, indicative of the rate of tr

SUBMITTER: Amponsah-Dacosta E 

PROVIDER: S-EPMC11598911 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature