Analysis of Memory Antibody Responses in Individuals with Zika-Associated Guillain-Barre Syndrome.

ABSTRACT: The Zika virus (ZIKV) was responsible for a major outbreak in 2015 in the Americas. Infections were associated with increased cases of microcephaly in infants and Guillain-Barré Syndrome (GBS) in adults. Our group previously demonstrated that Zika-associated GBS correlated with the increased neutralization of ZIKV and DENV2, but the antibody specificity was not analyzed. Here, we generated reporter virus particles (RVPs) of ZIKV with specific-point mutations that allowed us to investigate the specificity of circulating plasma antibodies at two different timepoints from individuals with Zika-associated GBS. We found that neutralizing antibody titers to ZIKV waned between one and two years post-ZIKV infection in GBS-negative but not GBS-positive individuals. Interestingly, plasma neutralizat

SUBMITTER: Premazzi Papa M 

PROVIDER: S-EPMC11598927 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature