Causal associations of ischemic stroke, metabolic factors, and related medications with epilepsy: a Mendelian randomization study.

ABSTRACT:

Background

Earlier researches have demonstrated that ischemic stroke, metabolic factors, and associated medications may influence the risk of epilepsy. Nevertheless, the causality between these elements and epilepsy remains inconclusive. This study aims to examine whether ischemic stroke, metabolic factors, and related medications affect the overall risk of epilepsy.

Methods

We used single nucleotide polymorphisms associated with ischemic stroke, hypothyroidism, hypertension, blood glucose levels, high cholesterol, serum 25-Hydroxyvitamin D levels, testosterone, HMG CoA reductase inhibitors, and beta-blocking agents as instrumental variables in a Mendelian randomization technique to investigate causality with epilepsy. Multiple sensitivity methods were performed to evaluate

SUBMITTER: Wang W 

PROVIDER: S-EPMC11598930 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature