Investigation of Polymorphisms Induced by the Solo Long Terminal Repeats (Solo-LTRs) in Porcine Endogenous Retroviruses (ERVs).

ABSTRACT: Homologous recombination events take place between the 5' and 3' long terminal repeats (LTRs) of ERVs, resulting in the generation of solo-LTR, which can cause solo-LTR-associated polymorphism across different genomes. In the current study, specific criteria were established for the filtration of solo-LTRs, resulting in an average of 5630 solo-LTRs being identified in 21 genomes. Subsequently, a protocol was developed for detecting solo-LTR polymorphisms in the pig genomes, resulting in the discovery of 927 predicted solo-LTR polymorphic sites. Following verification and filtration processes, 603 highly reliable solo-LTR polymorphic sites were retained, involving 446 solo-LTR presence sites (solo-LTR⁺) and 157 solo-LTR absence sites (solo-LTR^-) relative to the referen

SUBMITTER: Chen C 

PROVIDER: S-EPMC11598996 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature