The Low-Density Lipoprotein Receptor-Related Protein-1 Is Essential for Dengue Virus Infection.

ABSTRACT: Dengue virus (DENV) causes the most prevalent and rapidly spreading arboviral disease of humans. It enters human cells by receptor-mediated endocytosis. Numerous cell-surface proteins were proposed as DENV entry factors. Among these, the phosphatidylserine receptor TIM-1 is the only one known to mediate virus internalization. However, several cellular models lacking TIM-1 are permissive to DENV infection, suggesting that other receptors exist. Here, we show that the low-density lipoprotein receptor-related protein-1 (LRP1) binds DENV virions by interacting with the DIII of the viral envelope glycoprotein. DENV infection is effectively inhibited by the purified receptor at 5 × 10^-8 mol/L, and the interaction of the envelope protein with LRP1 is also blocked by a natural ligand of

SUBMITTER: Huerta V 

PROVIDER: S-EPMC11599027 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature