Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.

ABSTRACT: Diabetes mellitus involves both insufficient insulin secretion and dysregulation of glucagon secretion¹. In healthy people, a fall in plasma glucose stimulates glucagon release and thereby increases counter-regulatory hepatic glucose production. This response is absent in many patients with type-1 diabetes (T1D)², which predisposes to severe hypoglycaemia that may be fatal and accounts for up to 10% of the mortality in patients with T1D³. In rats with chemically induced or autoimmune diabetes, counter-regulatory glucagon secretion can be restored by SSTR antagonists^4-7 but both the underlying cellular mechanism and whether it can be extended to humans remain unestablished. Here, we show that glucagon secretion is not stimulated by low glucose in

SUBMITTER: Hill TG 

PROVIDER: S-EPMC11599053 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature