Nutrient transporter pattern in CD56^dim NK cells: CD16 (FcγRIIIA)-dependent modulation and association with memory NK cell functional profile.

ABSTRACT:

Background

Human memory NK cells represent a heterogeneous CD56^dim population that expands and persists in human cytomegalovirus (HCMV)-seropositive healthy individuals. They are characterized by the preferential, not fully overlapping, expression of NKG2C (activating receptor for HLA-E) and CD57 maturation marker, and by the lack of FcεRIγ adaptor chain. Hyperresponsiveness to Fcγ receptor IIIA (CD16) engagement represents the distinctive functional signature of memory NK cells. Although CD16 engagement was shown to acutely enhance glycolytic and oxidative pathways, its capability to induce a persisting metabolic reprogramming of human NK cells is poorly understood yet.

Results

Here, we describe the peculiar nutrient transporter expression pattern of FcεRIγ^-

SUBMITTER: De Federicis D 

PROVIDER: S-EPMC11599182 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature