Association of dementia with the 28-day mortality of sepsis: an observational and Mendelian randomization study.

ABSTRACT:

Background

Observational research suggests that individuals with dementia who have sepsis face a higher likelihood of death. However, whether there is a causal relationship between the two remains unknown.

Methods

We analyzed data from patients diagnosed with sepsis and dementia, extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. To examine the correlation between dementia and 28-day mortality in sepsis, we utilized Cox proportional hazards models. Following this, we performed a Mendelian randomization (MR) study with two samples to investigate the potential link between dementia and mortality within 28 days in sepsis.

Results

This study included a total of 22,189 patients diagnosed with sepsis, among whom 1,346 cases (6.1%) had dem

SUBMITTER: Lan Y 

PROVIDER: S-EPMC11599188 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature