Pathogenicity and identification of host adaptation genes of the avian pathogenic Escherichia coli O145 in duck.

ABSTRACT:

Introduction

Avian pathogenic Escherichia coli (APEC) is a critical bacterial pathogen that causes severe infections in poultry. Diverse serotypes increase the complexity of treatment and controlling APEC infections. Recent epidemiological investigations indicate O145 is emerging as a predominant serogroup of APEC in China. However, limited information is known about this newly emerged serogroup.

Methods

A virulent strain, NC22, was selected to elucidate the mechanisms underlying APEC O145-related pathogenicity and host adaptation. Whole-genome sequencing and pathogenicity assays was conducted on this strain. We further performed a transcriptional analysis of the bacteria during the early colonization stage in the duck liver and compared them with those in liquid cult

SUBMITTER: Tan MF 

PROVIDER: S-EPMC11599210 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature