Genetically predicted smoking and body mass index mediate the relationship between insomnia and myocardial infarction.

ABSTRACT:

Objective

This study aimed to investigate the causal relationship between insomnia and the risk of myocardial infarction (MI) and explore potential mediators such as smoking initiation, alcohol consumption and body mass index (BMI) using mendelian randomization (MR) analysis.

Methods

Data from 1,207,228 individuals of European ancestry were obtained from the UK Biobank and 23andMe for insomnia-related genetic associations. Genetic instruments for MI, smoking initiation, alcohol consumption, and BMI were derived from large-scale genome-wide association studies. Univariate MR analysis mainly utilized the inverse variance weighting method, and multivariable MR analysis assessed the mediation effects of smoking initiation and BMI.

Results

The univariate MR analysis reveal

SUBMITTER: Deng L 

PROVIDER: S-EPMC11599222 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature