A novel platelets-related gene signature for predicting prognosis, immune features and drug sensitivity in gastric cancer.

ABSTRACT:

Background

Platelets can dynamically regulate tumor development and progression. Nevertheless, research on the predictive value and specific roles of platelets in gastric cancer (GC) is limited. This research aims to establish a predictive platelets-related gene signature in GC with prognostic and therapeutic implications.

Methods

We downloaded the transcriptome data and clinical materials of GC patients (n=378) from The Cancer Genome Atlas (TCGA) database. Prognostic platelets-related genes screened by univariate Cox regression were included in Least Absolute Shrinkage and Selection Operator (LASSO) analysis to construct a risk model. Kaplan-Meier curves and receiver operating characteristic curves (ROCs) were performed in the TCGA cohort and three independent validation co

SUBMITTER: Li Q 

PROVIDER: S-EPMC11599260 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature