Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics.

ABSTRACT: Aging has profound effects on the body, most notably an increase in the prevalence of several diseases. An important aging hallmark is the presence of senescent cells that no longer multiply nor die off properly. Another characteristic is an altered immune system that fails to properly self-surveil. In this multi-player aging process, cellular senescence induces a change in the secretory phenotype, known as senescence-associated secretory phenotype (SASP), of many cells with the intention of recruiting immune cells to accelerate the clearance of these damaged senescent cells. However, the SASP phenotype results in inducing secondary senescence of nearby cells, resulting in those cells becoming senescent, and improper immune activation resulting in a state of chronic inflammation, called in

SUBMITTER: Venkataraman A 

PROVIDER: S-EPMC11599402 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature