The association of quantitative PSMA PET parameters with pathologic ISUP grade: an international multicenter analysis.

ABSTRACT:

Purpose

To assess if PSMA PET quantitative parameters are associated with pathologic ISUP grade group (GG) and upgrading/downgrading.

Methods

PCa patients undergoing radical prostatectomy with or without pelvic lymph node dissection staged with preoperative PSMA PET at seven referral centres worldwide were evaluated. PSMA PET parameters which included SUV_max, PSMA_volume, and total PSMA accumulation (PSMA_total) were collected. Multivariable logistic regression evaluated the association between PSMA PET quantified parameters and surgical ISUP GG. Decision-tree analysis was performed to identify discriminative thresholds for all three parameters related to the five ISUP GGs The ROC-derived AUC was used to determine whether the inclusion of PSMA

SUBMITTER: Soeterik TFW 

PROVIDER: S-EPMC11599533 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature