Proteomics analysis of extracellular vesicles for biomarkers of autism spectrum disorder.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by symptoms that include social interaction deficits, language difficulties and restricted, repetitive behavior. Early intervention through medication and behavioral therapy can eliminate some ASD-related symptoms and significantly improve the life-quality of the affected individuals. Currently, the diagnosis of ASD is highly limited.

Methods

To investigate the feasibility of early diagnosis of ASD, we tested extracellular vesicles (EVs) proteins obtained from ASD cases. First, plasma EVs were isolated from healthy controls (HCs) and ASD individuals and were analyzed using proximity extension assay (PEA) technology to quantify 1,196 protein expression level. Second, machine learning anal

SUBMITTER: Ali Moussa HY 

PROVIDER: S-EPMC11599737 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature