Severe toxicities in amazonian populations and the role of precision medicine in acute lymphoblastic leukemia treatment.

ABSTRACT: Corticosteroids, such as prednisone or dexamethasone, constitute integral components of antineoplastic regimens for Acute Lymphoblastic Leukemia (ALL) therapy, albeit accompanied by significant adverse effects. The multifactorial nature of interindividual variability in drug response, encompassing genetic polymorphisms, underscores the complexity of pharmacotherapy outcomes. However, pharmacogenetic investigations hitherto have predominantly focused on cohorts of European and North American descent, thus limiting the generalizability of findings to populations with minimal representation. Indigenous populations in Brazil, particularly those inhabiting the Amazon region, exhibit a distinctive genetic heritage, predominantly characterized by Native American ancestry. These populations freque

SUBMITTER: Leitao LPC 

PROVIDER: S-EPMC11599904 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature