Vascular insult in neonatal retinal hemorrhage: computational analysis of a fundus-segmented blood vessel network.

ABSTRACT: Common hypotheses for the biomechanical cause underlying neonatal retinal hemorrhage include elevated intracranial pressure (ICP) inducing venous outflow obstruction and retinal deformation. A finite element computational model of the eye, optic nerve, and orbit was simulated with particular attention to the retinal vessels to analyze stress and strain on these structures during external head compression associated with normal vaginal delivery. Pressure from maternal contractions displaced the eye backward into the orbit, and the stiff optic nerve sheath provided localized resistance to this posterior displacement at its insertion point, resulting in tensile strain of 2.5% in the peripapillary (central) retina. Correspondingly, retinal vessels experienced tensile stress of up to 2.3 kPa ne

SUBMITTER: Lam MR 

PROVIDER: S-EPMC11599931 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature