Neutrophil dynamics in pulmonary fibrosis: pathophysiological and therapeutic perspectives.

ABSTRACT: The shared pathobiological mechanisms driving progressive fibrosis in interstitial lung diseases (ILDs) remain unclear. Neutrophils, the most common immune cells in the human body, contain an extensive array of proteinases that are important for cell function, including tissue repair and remodelling. Increasing observational studies have reported elevated neutrophil counts in the respiratory tract and circulation of patients with ILD and suggest a role as a biomarker of disease severity. Neutrophils and their contents (including the formation of neutrophil extracellular traps (NETs)) are present in fibrotic lung tissue. Proteinases and NETs may drive fibrogenesis in animal and in vitro models and may impact transforming growth factor-β1 activation. However, the effect of neutrophil

SUBMITTER: Crowley LE 

PROVIDER: S-EPMC11600124 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature