C2-Linked Arabinose-Functionalized Polystyrene Microbeads Selectively Target <i>Staphylococcus aureus</i>.

ABSTRACT: Carbohydrates play pivotal roles in the first stages of microbial infections and can be exploited as decoys to hijack the interactions between bacteria and the host cell. Multivalent glycan probes mimicking the natural presentation of glycans in living cells have been successfully employed to study fundamental carbohydrate/protein interactions in microbial systems; however, most pathogenic glycan receptors exhibit a shared specificity for commonly found sugars present in both healthy and pathogenic cells, posing a challenge for target selectivity. In this study, we report the synthesis of a small library of d-arabinose multivalent probes, a sugar absent in human physiology, and their evaluation in a bacteria agglutination assay using cluster analysis. Our findings reveal preferential bindi

SUBMITTER: Walke G 

PROVIDER: S-EPMC11600162 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature