Nicotinamide Riboside and CD38: Covalent Inhibition and Live-Cell Labeling.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD⁺) is required for a myriad of metabolic, signaling, and post-translational events in cells. Its levels in tissues and organs are closely associated with health conditions. The homeostasis of NAD⁺ is regulated by biosynthetic pathways and consuming enzymes. As a membrane-bound protein with robust NAD⁺ hydrolase activity, cluster of differentiation 38 (CD38) is a major degrader of NAD⁺. Deficiency or inhibition of CD38 enhances NAD⁺ levels in vivo, resulting in various therapeutic benefits. As a metabolic precursor of NAD⁺, nicotinamide mononucleotide can be rapidly hydrolyzed by CD38, whereas nicotinamide riboside (NR) lacks CD38 substrate activity. Given their structural similarities, w

SUBMITTER: Kao G 

PROVIDER: S-EPMC11600175 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature