EF-Hand Battle Royale: Hetero-ion Complexation in Lanmodulin.

ABSTRACT: The lanmodulin (LanM) protein has emerged as an effective means for rare earth element (REE) extraction and separation from complex feedstocks without the use of organic solvents. Whereas the binding of LanM to individual REEs has been well characterized, little is known about the thermodynamics of mixed metal binding complexes (i.e., heterogeneous ion complexes), which limits the ability to accurately predict separation performance for a given metal ion mixture. In this paper, we employ the law of mass action to establish a theory of perfect cooperativity for LanM-REE complexation at the two highest-affinity binding sites. The theory is then used to derive an equation that explains the nonintuitive REE binding behavior of LanM, where separation factors for binary pairs of ions vary widely

SUBMITTER: Seidel J 

PROVIDER: S-EPMC11600183 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature