EDNRA regulates the tumour immune environment and predicts the efficacy and prognosis of cancer immunotherapy.

ABSTRACT: The potential role of endothelin receptor A (EDNRA) in cancer immunotherapy has been demonstrated; however, the mechanism of its therapeutic value remains to be investigated. This study aimed to reveal the potential link between cancer immunotherapy and EDNRA in human tumours. Clinical characteristics and gene expression information were acquired from the Cancer Genome Atlas database. The correlation between EDNRA expression and immune infiltration was analysed by tumour immune estimation resource (TIMER) and tumour-immune system interaction database (TISIDB). EDNRA expression in different cancer types were performed via qPCR. Immunohistochemistry was used to detect the relationships between EDNRA protein and immune checkpoints. The results have founded that EDNRA was differentially expres

SUBMITTER: Wang M 

PROVIDER: S-EPMC11600291 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature