Prospective and challenges of locally applied repurposed pharmaceuticals for periodontal tissue regeneration.

ABSTRACT: Periodontitis is a persistent inflammatory condition that causes periodontal ligament degradation, periodontal pocket development, and alveolar bone destruction, all of which lead to the breakdown of the teeth's supporting system. Periodontitis is triggered by the accumulation of various microflora (especially anaerobes) in the pockets, which release toxic substances and digestive enzymes and stimulate the immune system. Periodontitis can be efficiently treated using a variety of techniques, both regional and systemic. Effective therapy is dependent on lowering microbial biofilm, minimizing or eradicating pockets. Nowadays, using local drug delivery systems (LDDSs) as an adjuvant therapy to phase I periodontal therapy is an attractive option since it controls drug release, resulting in imp

SUBMITTER: El-Nablaway M 

PROVIDER: S-EPMC11600316 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature