Development of Human Monoclonal Antibodies With Broad Reactivity for Rabies Postexposure Prophylaxis.

ABSTRACT: Rabies is an acute lethal disease causing by the neurotropic virus rabies virus (RABV). Rabies immune globulin (RIG) as an indispensable component of rabies postexposure prophylaxis (PEP) always faces with great challenges in terms of costs, stability and safety. Our objective is to develop a novel and potential fully human monoclonal antibodies (mAbs) cocktail for the improvement of rabies PEP. The neutralizing fully human mAbs were screened by using fully humanized antibody mice (CAMouse^HG). Then, two mAbs 26-12 G and 5-7 G were selected with potential neutralizing activity to RABV by using fluorescent antibody virus neutralization test (FAVN), which specifically bind to antigenic sites I and III of RABV-glycoprotein (RABV-G), the key amino acid residues were further identifie

SUBMITTER: Wu M 

PROVIDER: S-EPMC11600393 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature