Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model.

ABSTRACT: Cellular senescence, characterized by expressing the cell cycle inhibitory proteins, is evident in driving age-related diseases. Senescent cells play a crucial role in the initiation and progression of tau-mediated pathology, suggesting that targeting cell senescence offers a therapeutic potential for treating tauopathy associated diseases. This study focuses on identifying non-invasive biomarkers and validating their responses to a well-characterized senolytic therapy combining dasatinib and quercetin (D + Q), in a widely used tauopathy mouse model, PS19. We employed human-translatable MRI measures, including water extraction with phase-contrast arterial spin tagging (WEPCAST) MRI, T2 relaxation under spin tagging (TRUST), longitudinally assessed brain physiology and high-resolution struc

SUBMITTER: Yao M 

PROVIDER: S-EPMC11600427 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature