Contemporary menopausal hormone therapy and risk of cardiovascular disease: Swedish nationwide register based emulated target trial.

ABSTRACT:

Objective

To assess the effect of contemporary menopausal hormone therapy on the risk of cardiovascular disease according to the route of administration and combination of hormones.

Design

Nationwide register based emulated target trial.

Setting

Swedish national registries.

Participants

919 614 women aged 50-58 between 2007 and 2020 without hormone therapy use in the previous two years, identified from the Swedish population.

Interventions

138 nested trials were designed, starting each month from July 2007 until December 2018. Using the prescription registry data for that specific month, women who had not used hormone therapy in the previous two years were assigned to one of eight treatment groups: oral combined continuous, oral combined sequential, oral

SUBMITTER: Johansson T 

PROVIDER: S-EPMC11600536 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature