Associations between serum levels of liver function biomarkers and all-cause and cause-specific mortality: a prospective cohort study.

ABSTRACT:

Background

The liver plays critical roles in human health. Circulating level of liver function biomarkers may associate with the long-term and short-term mortality in general population.

Methods

We used data from US National Health and Nutrition Examination Survey 1988-94 and 1999-2014. People aged ≥ 20 years with measured serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), total bilirubin (TB), and albumin (ALB) at baseline were included. All-cause and cause-specific mortality was identified from the National Death Index through 31 December 2015. Additive Cox regression models were applied to assess the correlation patterns between the serum level of these analytes and mortality risk.

SUBMITTER: Ling S 

PROVIDER: S-EPMC11600561 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature