Role of stretch-activated channels in light-generated action potentials mediated by an intramembrane molecular photoswitch.

ABSTRACT:

Background

The use of light to control the activity of living cells is a promising approach in cardiac research due to its unparalleled spatio-temporal selectivity and minimal invasiveness. Ziapin2, a newly synthesized azobenzene compound, has recently been reported as an efficient tool for light-driven modulation of excitation-contraction coupling (ECC) in human-induced pluripotent stem cells-derived cardiomyocytes. However, the exact biophysical mechanism of this process remains incompletely understood.

Methods

To address this, we performed a detailed electrophysiological characterization in a more mature cardiac model, specifically adult mouse ventricular myocytes (AMVMs).

Results

Our in vitro results demonstrate that Ziapin2 can photomodulate cardiac ECC in mature

SUBMITTER: Florindi C 

PROVIDER: S-EPMC11600573 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature