Dual-modal overcoming of physical barriers for improved photodynamic cancer therapy via soft organosilica nanocapsules.

ABSTRACT: Amidst the burgeoning field of cancer nanomedicine, dense extracellular matrices and anomalous vascular structures in the tumor microenvironment (TME) present substantial physical barriers to effective therapeutic delivery. These physical barriers hinder the optimal bioavailability of nanomedicine. Here, we propose a pioneering dual-modal strategy for overcoming physical barriers via soft organosilica nanocapsules (SMONs). Hyaluronidase-modified flexible spheres work by degrading the extracellular matrix and utilizing their flexible characteristics to enhance penetration into deeper layers. Compared with their stiff counterparts, the SMONs show diminished Young's modulus, then the inherent softness of the SMONs confers distinct advantages, and significantly augmented cellular internalizati

SUBMITTER: Lu W 

PROVIDER: S-EPMC11600580 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature