The protumorigenic enzyme GPAT2 inhibits arachidonic acid-triggered apoptosis in breast cancer.

ABSTRACT:

Background

Cancer is a significant health challenge and the leading cause of mortality globally. Tumor cells use multiple mechanisms to acquire their distinctive capacity for uncontrolled proliferation, one of which is the evasion of apoptosis. It has been shown that in breast, colon, and liver cancer, evasion of apoptosis is associated with the overexpression of enzymes that metabolize arachidonic acid (AA) because free AA is a strong inducer of apoptosis. Glycerol-3-phosphate acyltransferase 2 (GPAT2) is a key enzyme in AA metabolism and is highly expressed in breast and colon cancer, where it promotes the development of essential tumor features.

Methods

In this work, a model of GPAT2 silencing in the human breast cancer-derived cell line MDA-MB-231 was used, and the cells

SUBMITTER: Ferremi FJ 

PROVIDER: S-EPMC11600616 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature