Lnc-MEG8 regulates yak myoblast differentiation via the miR-22-3p/RTL1 axis.

ABSTRACT:

Background

The yak (Bos grunniens) is essential to the livelihoods of Tibetan people on the Qinghai-Tibet Plateau; however, its growth and productivity are constrained by the region's harsh climate and high altitude. Yak skeletal muscle myoblasts, which have evolved to thrive under these challenging conditions, offer a valuable model for investigating muscle development. In this study, we performed transcriptome profiling of yak longissimus dorsi muscle at different growth stages, identifying a key long non-coding RNA, LncRNA-XR_314844 (Lnc-MEG8), with a potential role in muscle development.

Results

We developed a novel technique to isolate high-quality yak myoblasts, enabling detailed analysis of Lnc-MEG8. Our results indicated that Lnc-MEG8's subcellular localization varie

SUBMITTER: Ma X 

PROVIDER: S-EPMC11600685 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature