Disulfiram-loaded nanovesicles hydrogel promotes healing of diabetic wound.

ABSTRACT:

Background

Traditional methods for treating diabetic wounds are limited in effectiveness because of their long healing times, the risk of immune rejection, and susceptibility to infection. Suppressing neutrophil extracellular traps (NETs) is an effective strategy for reducing persistent inflammation in diabetic wounds. Although disulfiram (DSF) can inhibit the significant increase of NETs in diabetic wounds, oral DSF suffers from rapid and harmful metabolism in the liver. To address these challenges, we developed a nanomedicine formulation in which DSF was incorporated into the hydrogel.

Methods

In this study, we developed a DSF-laden sodium alginate hydrogel wound dressing, DEP@SA, and characterized its composition, properties, and performance. We examined the effects of DE

SUBMITTER: Sun X 

PROVIDER: S-EPMC11600750 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature