Combining methylated RNF180 and SFRP2 plasma biomarkers for noninvasive diagnosis of gastric cancer.

ABSTRACT:

Introduction

Gastric cancer (GC) is a common malignant tumor, and early diagnosis significantly improves patient survival rates. This study aimed to investigate the diagnostic value of ring finger protein 180 (RNF180) and secreted frizzled protein 2 (SFRP2) in GC.

Materials & methods

A total of 165 healthy individuals, 34 patients with precancerous gastric lesions, and 104 patients with confirmed GC were divided into training and validation sets; methylated RNF180 and SFRP2 were detected in circulating DNA from blood samples. Six models, including those based on logistic regression, Naive Bayes, K-nearest neighbor algorithm, glmnet, neural network, and random forest (RF) were built and validated. Area under the curve (AUC), sensitivity, specificity, positive predictive value

SUBMITTER: Dai Z 

PROVIDER: S-EPMC11600768 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature