PIVKA-II but not dp-ucMGP is associated with aortic calcification in chronic kidney disease.

ABSTRACT:

Background

Patients with chronic kidney disease (CKD) are susceptible to vascular calcification and vitamin K deficiency. Matrix gla protein (MGP) is a potent inhibitor of calcification requiring vitamin K for activation. Inactive MGP, i.e. dephosphorylated uncarboxylated MGP (dp-ucMGP), is frequently elevated in CKD along with protein induced by vitamin K absence (PIVKA-II). We investigated whether dp-ucMGP and PIVKA-II are useful markers of aortic calcification in CKD.

Methods

Patients with normal or reduced kidney function underwent a non-contrast computed tomography scan of the entire aorta with subsequent blinded standard calcification scoring of the aortic wall ad modum Agatston. Blood samples were analyzed for plasma concentrations of dp-ucMGP and PIVKA-II.

Results

SUBMITTER: Nyvad J 

PROVIDER: S-EPMC11600904 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature