Association of depression with gastroesophageal reflux disease, and the mediating role of risk factors: a Mendelian randomization study.

ABSTRACT:

Background

Growing evidence suggests that depression affects gastroesophageal reflux disease (GERD). But, the relationship between depression and GERD is unclear. To examine the relationship between depression and the risk of GERD, as well as the mediating role of risk factors.

Methods

We found genetic variants associated with GERD (N = 78,707) and depression (N = 500,199 (excluding 23 and Me) from the largest genome-wide association study and we applied two-sample Mendelian randomization (MR) to find out if they are related. We further used two-step MR to find the mediating factors.

Results

The results found a causal link between depression and GERD, inverse-variance weighted (IVW), risk OR 2.149 (95% CI, 1.910 to 2.418; P <0.001). F-statistics for all instrum

SUBMITTER: Duan H 

PROVIDER: S-EPMC11600978 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature