Treatment of small as well as large declines in lung function enhances recovery to baseline in people with CF.

ABSTRACT:

Background

The benefit of antibiotic treatment of acute drops in FEV₁ percent predicted (FEV₁pp) has been clearly established, but data from the early 2000s showed inconsistent treatment. Further, there is no empirical evidence for what magnitude of drop is clinically significant.

Methods

We used data from the CF Foundation Patient Registry (CFFPR) from 2016 to 2019 to determine the association between treatment (any IV antibiotics, only oral or newly prescribed inhaled antibiotics, or no antibiotic therapy) following a decline of ≥5% from baseline FEV₁pp and return to 100% baseline FEV₁pp days using multivariable logistic regression including an interaction between the magnitude of decline and treatment category.

Results

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SUBMITTER: Schechter MS 

PROVIDER: S-EPMC11601011 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature