Optimized algorithm for speed-of-sound-based infant sulfur hexafluoride multiple-breath washout measurements.

ABSTRACT:

Introduction

Major methodological issues with the existing algorithm (WBreath) used for the analysis of speed-of-sound-based infant sulfur hexafluoride (SF₆) multiple-breath washout (MBW) measurements lead to implausible results and complicate the comparison between different age groups and centers.

Methods

We developed OASIS-a novel algorithm to analyze speed-of-sound-based infant SF₆ MBW measurements. This algorithm uses known context of the measurements to replace the dependence of WBreath on model input parameters. We validated the functional residual capacity (FRC) measurement accuracy of this new algorithm in vitro, and investigated its use in existing infant MBW data sets from different infant cohorts from Switzerland and South Africa.

Results

SUBMITTER: Wyler F 

PROVIDER: S-EPMC11601022 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature