Multimodal state-dependent connectivity analysis of arousal and autonomic centers in the brainstem and basal forebrain.

ABSTRACT: Vigilance is a continuously altering state of cortical activation that influences cognition and behavior and is disrupted in multiple brain pathologies. Neuromodulatory nuclei in the brainstem and basal forebrain are implicated in arousal regulation and are key drivers of widespread neuronal activity and communication. However, it is unclear how their large-scale brain network architecture changes across dynamic variations in vigilance state (i.e., alertness and drowsiness). In this study, we leverage simultaneous EEG and 3T multi-echo functional magnetic resonance imaging (fMRI) to elucidate the vigilance-dependent connectivity of arousal regulation centers in the brainstem and basal forebrain. During states of low vigilance, most of the neuromodulatory nuclei investigated here exhibit a

SUBMITTER: Pourmotabbed H 

PROVIDER: S-EPMC11601260 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature