Blood cultures contain populations of genetically diverse <i>Candida albicans</i> strains that may differ in echinocandin tolerance and virulence.

ABSTRACT: It is unknown whether within-patient Candida albicans diversity is common during bloodstream infections (BSIs). We determined whole genome sequences of 10 C. albicans strains from blood cultures (BCs) in each of 4 patients. BCs in 3 patients contained mixed populations of strains that differed by large-scale genetic variants, including chromosome (Chr) 5 or 7 aneuploidy (n=2) and Chr1 loss of heterozygosity (n=1). Chr7 trisomy (Tri7) strains from patient MN were attenuated for hyphal and biofilm formation in vitro compared to euploid strains, due at least in part to NRG1 over-expression. Nevertheless, representative Tri7 strain M1 underwent filamentation during disseminated candidiasis (DC) in mice. M1 was more fit than euploid strain M2 during DC and mou

SUBMITTER: Fleres G 

PROVIDER: S-EPMC11601265 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature