Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism.

ABSTRACT: Alzheimer's disease (AD) affects more women than men. Although women live longer than men, it is not longevity alone, but other factors, including metabolic changes, that contribute to the higher risk of AD in women. Metabolic pathways have been implicated in AD progression, but studies to date examined targeted pathways, leaving many metabolites unmeasured. Sex is often a neglected biological variable, and most metabolomic studies were not designed to investigate sex differences in metabolomic profiles. Here, we performed untargeted metabolomic profiling of sera from male and female patients with mild cognitive impairment (MCI), a common precursor to AD, and matched controls. We discovered significant metabolic changes in individuals with MCI, and found several pathways that were strongly

SUBMITTER: Escarcega RD 

PROVIDER: S-EPMC11601308 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature