Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild Traumatic Brain Injury.

ABSTRACT: Astrocytes play a crucial role in maintaining brain homeostasis through functional gap junctions (GJs) primarily formed by connexin43 (Cx43). These GJs facilitate electrical and metabolic coupling between astrocytes, allowing the passage of ions, glucose, and metabolites. Dysregulation of Cx43 has been implicated in various pathologies, including traumatic brain injury (TBI) and acquired epilepsy. We previously identified a subset of atypical astrocytes after mild TBI that exhibit reduced Cx43 expression and coupling and are correlated with the development of spontaneous seizures. Given that mild TBI affects millions globally and can lead to long-term complications, including post-traumatic epilepsy, understanding the molecular events post-TBI is critical for developing therapeutic strateg

SUBMITTER: Munoz-Ballester C 

PROVIDER: S-EPMC11601309 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature