ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures.

ABSTRACT: Key amino acid positions that are important for maintaining the 3D structure of a protein and/or its function(s), e.g. catalytic activity, binding to ligand, DNA or other proteins, are often under strong evolutionary constraints. Thus, the biological importance of a residue often correlates with its level of evolutionary conservation within the protein family. ConSurf (http://consurf.tau.ac.il/) is a web-based tool that automatically calculates evolutionary conservation scores and maps them on protein structures via a user-friendly interface. Structurally and functionally important regions in the protein typically appear as patches of evolutionarily conserved residues that are spatially close to each other. We present here version 3.0 of ConSurf. This new version includes an empirical Baye

SUBMITTER: Landau M 

PROVIDER: S-EPMC1160131 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature