Time-Dependent Material Properties and Composition of the Nonhuman Primate Uterine Layers Through Gestation.

ABSTRACT: The uterus is central to the establishment, maintenance, and delivery of a healthy pregnancy. Biomechanics is an important contributor to pregnancy success, and alterations to normal uterine biomechanical functions can contribute to an array of obstetric pathologies. Few studies have characterized the passive mechanical properties of the gravid human uterus, and ethical limitations have largely prevented the investigation of mid-gestation periods. To address this key knowledge gap, this study seeks to characterize the structural, compositional, and time-dependent micro-mechanical properties of the nonhuman primate (NHP) uterine layers in nonpregnancy and at three time-points in pregnancy: early 2^nd, early 3^rd, and late 3^rd trimesters. Distinct material and

SUBMITTER: Fodera DM 

PROVIDER: S-EPMC11601338 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature