PhyloDome--visualization of taxonomic distributions of domains occurring in eukaryote protein sequence sets.

ABSTRACT: The analysis of taxonomic distribution and lineage-specific variation of domains and domain combinations is an important step in the assessment of their functional roles and potential interoperability. In the study of eukaryote sequence sets with many multi-domain proteins, it can become laborious to evaluate the phylogenetic context of the many occurring domains and their mutual relationships. PhyloDome is an answer to that problem. It provides a fast overview on the taxonomic spreading and potential interrelation of domains that are either given as a list of names and PFAM/SMART accessions or derived from a user-defined set of sequences. This taxonomic distribution analysis can be helpful in protein function and interaction assignment as the comparative study of potential Hedgehog pathwa

SUBMITTER: Novatchkova M 

PROVIDER: S-EPMC1160134 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature